Molecular and cytogenetic analysis of solid tumors
نویسنده
چکیده
In this lecture two-part lecture we will focus on the importance of cytogenetics and molecular biology in understanding the causation of solid tumors and on how this information is being developed for the clinical laboratory. We will review the recurrent rearrangements in some of the pediatric neoplasms and relate the observed changes to the molecular biology that underlies these cancers. The role of cytogenetics, FISH and molecular diagnostics as performed in Toronto will be reviewed using the management of Ewing and rhabdomyosarcomas as examples. The research applications of comparative genomic hybridization (CGH) and spectral karyotyping (SKY) will be discussed drawing on examples from brain tumors, osteosarcoma, retinoblastoma, ovarian and prostate cancer.
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